Connect with our innovative medical technology team to explore partnership opportunities and discuss how we can work together

Meet the LumenGuides Team - Collaboration Discussion

Online Meeting

LumenGuides

<div style="max-width: 800px; margin: 0 auto; padding: 20px; font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif; line-height: 1.6; color: #31322f;"><h1 style="color: #4f9dc4; font-size: 2.5em; margin-bottom: 20px; text-align: center; border-bottom: 3px solid #6cbfa7; padding-bottom: 15px;">Revolutionizing Lung Cancer Detection: LumenGuides' Breakthrough Naviscope Technology</h1><img src="https://res.cloudinary.com/salesfronts/image/upload/v1751884982/trans_square_gtfvc5.png" alt="LumenGuides Naviscope autonomous bronchoscopy system" style="width: 100%; max-width: 600px; height: 300px; object-fit: cover; border-radius: 10px; margin: 20px auto; display: block; box-shadow: 0 4px 8px rgba(0,0,0,0.1);"><p style="font-size: 1.1em; margin-bottom: 25px; text-align: center; font-style: italic; color: #4f9dc4;">The future of lung cancer detection is here, and it's radiation-free, autonomous, and revolutionary.</p><p style="margin-bottom: 20px;">At <strong style="color: #4f9dc4;">LumenGuides</strong>, we're not just developing another medical device – we're pioneering a complete paradigm shift in early-stage lung cancer detection. Our groundbreaking <strong>Naviscope</strong> system represents the world's first single-use, radiation-free, AI-powered bronchoscopy solution that operates autonomously, eliminating the need for external imaging or operator dependency.</p><h2 style="color: #6cbfa7; font-size: 1.8em; margin-top: 35px; margin-bottom: 20px; border-left: 4px solid #4f9dc4; padding-left: 15px;">The Technology Behind the Revolution</h2><p style="margin-bottom: 20px;">What makes Naviscope truly revolutionary is its innovative combination of <strong>fiber optic sensors (FBGs)</strong> with advanced AI architectures and sophisticated algorithms. This powerful fusion enables our system to autonomously navigate to peripheral lung lesions – including those that are currently impossible to reach using standard bronchoscopes or even existing robotic systems.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1751884982/trans_square_gtfvc5.png" alt="Fiber optic sensor technology in medical bronchoscopy" style="width: 100%; max-width: 500px; height: 250px; object-fit: cover; border-radius: 8px; margin: 20px auto; display: block; float: right; margin-left: 20px; box-shadow: 0 3px 6px rgba(0,0,0,0.1);"><p style="margin-bottom: 20px;">The elimination of radiation exposure is not just a technical achievement – it's a patient safety revolution. Traditional imaging-guided procedures expose patients to harmful radiation, while our system provides precise navigation through advanced optical sensing technology. This breakthrough makes lung biopsies safer, more accessible, and significantly more cost-effective.</p><h2 style="color: #6cbfa7; font-size: 1.8em; margin-top: 35px; margin-bottom: 20px; border-left: 4px solid #4f9dc4; padding-left: 15px; clear: both;">2025: A Year of Remarkable Milestones</h2><p style="margin-bottom: 15px;">Our journey in 2025 has been nothing short of extraordinary. Here's what we've accomplished:</p><ul style="margin-bottom: 25px; padding-left: 30px;"><li style="margin-bottom: 10px; color: #31322f;"><strong style="color: #4f9dc4;">✅ Company Launch (Q1 2025):</strong> LumenGuides officially began its mission to transform lung diagnostics</li><li style="margin-bottom: 10px;"><strong style="color: #4f9dc4;">✅ US Patent Filed (March 2025):</strong> Secured intellectual property protection for our innovative technology</li><li style="margin-bottom: 10px;"><strong style="color: #4f9dc4;">✅ $1M Angel Investment (May-September 2025):</strong> Successfully raised initial funding from visionary investors</li><li style="margin-bottom: 10px;"><strong style="color: #4f9dc4;">✅ Maximum Seed Track Grant:</strong> Received 5.5M NIS from the Israel Innovation Authority for female-led nested deeptech</li><li style="margin-bottom: 10px;"><strong style="color: #4f9dc4;">✅ Proof-of-Concept Complete:</strong> Developed and validated our functional MVP</li><li style="margin-bottom: 10px;"><strong style="color: #4f9dc4;">✅ First Pre-Clinical Success:</strong> Completed successful pig study at Assaf Harofeh in early September</li><li style="margin-bottom: 10px;"><strong style="color: #6cbfa7;">🔜 Second Pre-Clinical Study:</strong> Currently preparing for our next validation phase</li></ul><h2 style="color: #6cbfa7; font-size: 1.8em; margin-top: 35px; margin-bottom: 20px; border-left: 4px solid #4f9dc4; padding-left: 15px;">The Market Opportunity: A $17 Billion Revolution</h2><img src="https://res.cloudinary.com/salesfronts/image/upload/v1751884982/trans_square_gtfvc5.png" alt="Global bronchoscopy market growth and opportunities" style="width: 100%; max-width: 400px; height: 200px; object-fit: cover; border-radius: 8px; margin: 15px auto; display: block; float: left; margin-right: 20px; box-shadow: 0 3px 6px rgba(0,0,0,0.1);"><p style="margin-bottom: 20px;">The numbers speak for themselves. The global bronchoscopy market is projected to reach <strong style="color: #4f9dc4;">$17 billion by 2030</strong>, driven by an urgent unmet need for radiation-free, operator-independent solutions. Current robotic systems are prohibitively expensive and complex, creating a significant barrier to widespread adoption.</p><p style="margin-bottom: 20px;">Naviscope addresses this challenge head-on by being approximately <strong style="color: #6cbfa7;">90% more affordable</strong> than existing robotic systems, while delivering superior autonomous navigation capabilities. This cost-effectiveness, combined with our radiation-free approach, positions us to capture a substantial share of this rapidly growing market.</p><h2 style="color: #6cbfa7; font-size: 1.8em; margin-top: 35px; margin-bottom: 20px; border-left: 4px solid #4f9dc4; padding-left: 15px; clear: both;">Funding the Future: $4M Seed Round</h2><p style="margin-bottom: 15px;">We're currently raising a <strong style="color: #4f9dc4;">$4 million Seed Round</strong> to accelerate our path to market. These funds will enable us to:</p><ul style="margin-bottom: 25px; padding-left: 30px;"><li style="margin-bottom: 8px;"><strong>Final Design Freeze + Verification & Validation:</strong> Complete our product development cycle</li><li style="margin-bottom: 8px;"><strong>Pre-Clinical Animal Studies:</strong> Finish comprehensive validation testing</li><li style="margin-bottom: 8px;"><strong>Clinical Pilot Program:</strong> Conduct trials with 30 patients across 3+ hospitals</li><li style="margin-bottom: 8px;"><strong>FDA Regulatory Path:</strong> Navigate 510(k) approval process with predicate K242070</li></ul><h2 style="color: #6cbfa7; font-size: 1.8em; margin-top: 35px; margin-bottom: 20px; border-left: 4px solid #4f9dc4; padding-left: 15px;">World-Class Clinical Collaborations</h2><p style="margin-bottom: 20px;">We're privileged to work alongside leading medical professionals who share our vision:</p><div style="background-color: #ffffff; border: 2px solid #6cbfa7; border-radius: 10px; padding: 20px; margin: 20px 0; box-shadow: 0 2px 4px rgba(0,0,0,0.1);"><p style="margin-bottom: 10px;"><strong style="color: #4f9dc4;">Prof. Mordechai Kramer</strong><br>Head of Pulmonary Medicine, Rabin Medical Center</p><p style="margin-bottom: 0;"><strong style="color: #4f9dc4;">Prof. Eli Attar</strong><br>Head of Imaging, Rabin Medical Center</p></div><h2 style="color: #6cbfa7; font-size: 1.8em; margin-top: 35px; margin-bottom: 20px; border-left: 4px solid #4f9dc4; padding-left: 15px;">Join the Revolution</h2><img src="https://res.cloudinary.com/salesfronts/image/upload/v1751884982/trans_square_gtfvc5.png" alt="LumenGuides team and future of lung cancer detection" style="width: 100%; max-width: 600px; height: 250px; object-fit: cover; border-radius: 10px; margin: 20px auto; display: block; box-shadow: 0 4px 8px rgba(0,0,0,0.1);"><p style="margin-bottom: 20px;">At LumenGuides, we're not just building a product – we're reshaping the future of lung biopsies and early cancer detection. Our autonomous, radiation-free approach represents a fundamental shift toward safer, more accessible, and more effective patient care.</p><p style="margin-bottom: 25px;">I invite you to learn more about our groundbreaking work and explore how Naviscope is transforming the landscape of pulmonary medicine. Visit our website at <a href="https://lumenguides.com" style="color: #4f9dc4; text-decoration: none; font-weight: bold;">lumenguides.com</a> or reach out directly for a personalized demonstration.</p><div style="background-color: #4f9dc4; color: #ffffff; padding: 25px; border-radius: 10px; text-align: center; margin-top: 30px;"><p style="margin-bottom: 15px; font-size: 1.1em;"><strong>Ready to be part of the future of lung cancer detection?</strong></p><p style="margin-bottom: 10px;">Limor Prigan, ChE, MBA<br>Founder & CEO | LumenGuides</p><p style="margin-bottom: 0;">📧 <a href="mailto:limor@lumenguides.com" style="color: #ffffff; text-decoration: underline;">limor@lumenguides.com</a></p></div></div>

LumenGuides unveils Naviscope, the world's first autonomous, radiation-free bronchoscopy system powered by AI and fiber optic sensors, raising $4M to transform early-stage lung cancer detection.

Revolutionizing Lung Cancer Detection: LumenGuides Introduces Naviscope

<div style="max-width: 900px; margin: 0 auto; font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif; line-height: 1.8; color: #31322f; padding: 20px;"><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865271/generated-sections/oc7dggz2z81chrj6edq8.jpg" alt="LumenGuides Naviscope autonomous robotic bronchoscopy system" style="width: 100%; max-width: 100%; height: auto; border-radius: 12px; margin-bottom: 30px; box-shadow: 0 4px 12px rgba(0,0,0,0.1);" /><h1 style="font-size: 2.5em; font-weight: 700; color: #4f9dc4; margin-bottom: 20px; line-height: 1.3;">LumenGuides Achieves Two Major Milestones: First Animal Pilot & ₪5.5M IIA Grant</h1><p style="font-size: 1.15em; color: #31322f; margin-bottom: 25px; font-style: italic; border-left: 4px solid #6cbfa7; padding-left: 20px; background: #f9f9f9; padding: 15px 20px; border-radius: 6px;">Autonomous robotic navigation takes another leap forward as LumenGuides demonstrates breakthrough technology in lung diagnostics and secures maximum national R&D funding.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 40px; margin-bottom: 20px; border-bottom: 3px solid #6cbfa7; padding-bottom: 10px;">🎯 Milestone #1: First Pre-Clinical Animal Pilot – September 4, 2025</h2><p style="margin-bottom: 20px; font-size: 1.05em;">On September 4, 2025, LumenGuides reached a defining moment in medical innovation. Our <strong style="color: #4f9dc4;">Naviscope</strong> — the world's first autonomous, single-use robotic bronchoscopy system — successfully navigated deep into the lung of our first in-vivo model at <strong>Shamir Medical Center (Asaf Harofeh)</strong>.</p><p style="margin-bottom: 20px; font-size: 1.05em;">What makes this achievement groundbreaking?</p><ul style="margin-left: 25px; margin-bottom: 25px; font-size: 1.05em; line-height: 1.9;"><li style="margin-bottom: 12px;"><strong style="color: #6cbfa7;">Autonomous Navigation:</strong> The device independently advanced through multiple airway branches with precision and safety.</li><li style="margin-bottom: 12px;"><strong style="color: #6cbfa7;">Continuous Respiratory Motion:</strong> Naviscope operated seamlessly under real-world physiological conditions.</li><li style="margin-bottom: 12px;"><strong style="color: #6cbfa7;">No Radiation Required:</strong> Unlike traditional methods, our system eliminates the need for external imaging or fluoroscopy.</li><li style="margin-bottom: 12px;"><strong style="color: #6cbfa7;">Operator-Independent:</strong> The technology doesn't rely on manual skill, reducing variability and improving outcomes.</li></ul><p style="margin-bottom: 25px; font-size: 1.05em; background: #f0f8ff; padding: 20px; border-radius: 8px; border-left: 5px solid #4f9dc4;">This pilot validates the core promise of our technology: <strong>reaching peripheral lung lesions that are currently inaccessible to standard and robotic bronchoscopes</strong> — safely, precisely, and without radiation exposure.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865271/generated-sections/oc7dggz2z81chrj6edq8.jpg" alt="Naviscope autonomous navigation system in action during animal pilot" style="width: 100%; max-width: 100%; height: auto; border-radius: 10px; margin: 30px 0; box-shadow: 0 6px 16px rgba(0,0,0,0.12);" /><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-bottom: 3px solid #6cbfa7; padding-bottom: 10px;">🏆 Milestone #2: Israel Innovation Authority Seed Track Grant – September 11, 2025</h2><p style="margin-bottom: 20px; font-size: 1.05em;">Just one week after our successful animal pilot, on September 11, 2025, we received another powerful endorsement: LumenGuides has been awarded the <strong style="color: #4f9dc4; font-size: 1.1em;">maximum R&D grant of ₪5.5M</strong> from the Israel Innovation Authority (IIA) under their prestigious Seed Track program.</p><p style="margin-bottom: 25px; font-size: 1.05em;">This grant represents far more than financial support — it's a <strong>strong national endorsement</strong> of:</p><ul style="margin-left: 25px; margin-bottom: 30px; font-size: 1.05em; line-height: 1.9;"><li style="margin-bottom: 12px;">Our <strong style="color: #6cbfa7;">breakthrough technology</strong> and its potential to transform lung diagnostics</li><li style="margin-bottom: 12px;">The <strong style="color: #6cbfa7;">expertise and vision</strong> of our founding team</li><li style="margin-bottom: 12px;">The <strong style="color: #6cbfa7;">clinical impact</strong> we're positioned to deliver in early lung cancer detection</li><li style="margin-bottom: 12px;">Our clear <strong style="color: #6cbfa7;">regulatory pathway</strong> and commercial viability</li></ul><p style="margin-bottom: 25px; font-size: 1.05em; background: #f0fff4; padding: 20px; border-radius: 8px; border-left: 5px solid #6cbfa7;">With this funding, we're accelerating our path toward GLP pre-clinical studies, design freeze, and a <strong>30-patient multi-site clinical pilot</strong> — all aligned with our FDA 510(k) regulatory strategy.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-bottom: 3px solid #6cbfa7; padding-bottom: 10px;">🔬 About LumenGuides: Pioneering Autonomous Lung Diagnostics</h2><p style="margin-bottom: 20px; font-size: 1.05em;">Founded earlier this year, <strong>LumenGuides</strong> is on a mission to revolutionize early lung cancer detection. Our flagship product, <strong style="color: #4f9dc4;">Naviscope</strong>, is the world's first autonomous, radiation-free, single-use navigation system designed specifically for interventional pulmonology.</p><h3 style="font-size: 1.5em; font-weight: 600; color: #6cbfa7; margin-top: 30px; margin-bottom: 15px;">How Naviscope Works</h3><p style="margin-bottom: 20px; font-size: 1.05em;">Naviscope leverages cutting-edge technologies to overcome the limitations of current bronchoscopy systems:</p><ul style="margin-left: 25px; margin-bottom: 25px; font-size: 1.05em; line-height: 1.9;"><li style="margin-bottom: 12px;"><strong style="color: #4f9dc4;">Fiber-Optic Sensors (FBGs):</strong> Real-time 3D airway mapping from inside the lungs</li><li style="margin-bottom: 12px;"><strong style="color: #4f9dc4;">AI-Powered Guidance:</strong> Intelligent navigation algorithms ensure precision and safety</li><li style="margin-bottom: 12px;"><strong style="color: #4f9dc4;">Autonomous Operation:</strong> Reduces dependency on operator skill and experience</li><li style="margin-bottom: 12px;"><strong style="color: #4f9dc4;">Radiation-Free:</strong> No CT, fluoroscopy, or electromagnetic navigation required</li></ul><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865271/generated-sections/oc7dggz2z81chrj6edq8.jpg" alt="LumenGuides technology diagram showing fiber-optic sensing and AI navigation" style="width: 100%; max-width: 100%; height: auto; border-radius: 10px; margin: 30px 0; box-shadow: 0 6px 16px rgba(0,0,0,0.12);" /><h3 style="font-size: 1.5em; font-weight: 600; color: #6cbfa7; margin-top: 35px; margin-bottom: 15px;">The Clinical Need</h3><p style="margin-bottom: 20px; font-size: 1.05em;">Current bronchoscopy systems fail to reach approximately <strong>40% of lung nodules</strong>, particularly those in peripheral locations. This limitation means:</p><ul style="margin-left: 25px; margin-bottom: 25px; font-size: 1.05em; line-height: 1.9;"><li style="margin-bottom: 12px;">Delayed diagnosis of early-stage lung cancer</li><li style="margin-bottom: 12px;">Patients requiring more invasive procedures</li><li style="margin-bottom: 12px;">Higher costs (competing procedures can exceed $20,000)</li><li style="margin-bottom: 12px;">Increased radiation exposure and procedural risks</li></ul><p style="margin-bottom: 25px; font-size: 1.05em;">Naviscope is designed to reach these previously inaccessible nodules, enabling earlier detection and treatment when outcomes are most favorable.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-bottom: 3px solid #6cbfa7; padding-bottom: 10px;">🚀 What's Next: Our Roadmap to Clinical Impact</h2><p style="margin-bottom: 20px; font-size: 1.05em;">With these two major milestones achieved, LumenGuides is advancing rapidly toward commercial readiness:</p><div style="background: linear-gradient(135deg, #f0f8ff 0%, #f0fff4 100%); padding: 25px; border-radius: 10px; margin: 25px 0; border: 2px solid #6cbfa7;"><h3 style="font-size: 1.4em; font-weight: 600; color: #4f9dc4; margin-bottom: 15px;">Upcoming Milestones</h3><ul style="margin-left: 20px; font-size: 1.05em; line-height: 2;"><li style="margin-bottom: 12px;"><strong>Q4 2025:</strong> Complete GLP pre-clinical studies</li><li style="margin-bottom: 12px;"><strong>Q1 2026:</strong> Achieve design freeze and verification & validation (V&V)</li><li style="margin-bottom: 12px;"><strong>Q2-Q3 2026:</strong> Launch 30-patient multi-site clinical pilot</li><li style="margin-bottom: 12px;"><strong>Q4 2026:</strong> Submit FDA 510(k) application</li><li style="margin-bottom: 12px;"><strong>2027:</strong> Prepare for Series A fundraising and commercial launch</li></ul></div><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-bottom: 3px solid #6cbfa7; padding-bottom: 10px;">💼 Investment Opportunity: Join the Revolution in Lung Diagnostics</h2><p style="margin-bottom: 20px; font-size: 1.05em;">With our recent technical and financial milestones achieved, LumenGuides is currently raising <strong style="color: #4f9dc4; font-size: 1.15em;">$1.5M</strong> to complete our <strong>$4M Seed Round</strong>, scheduled to close on <strong>February 1, 2026</strong>.</p><p style="margin-bottom: 20px; font-size: 1.05em;">This funding will enable us to:</p><ul style="margin-left: 25px; margin-bottom: 30px; font-size: 1.05em; line-height: 1.9;"><li style="margin-bottom: 12px;">Complete our pilot study demonstrating safety and efficacy</li><li style="margin-bottom: 12px;">File our FDA 510(k) submission</li><li style="margin-bottom: 12px;">Unlock the full $4M IIA grant</li><li style="margin-bottom: 12px;">Prepare for Series A fundraising</li></ul><div style="background: #4f9dc4; color: #ffffff; padding: 30px; border-radius: 12px; margin: 35px 0; text-align: center; box-shadow: 0 8px 20px rgba(79,157,196,0.3);"><h3 style="font-size: 1.6em; font-weight: 700; margin-bottom: 15px; color: #ffffff;">Why Invest in LumenGuides?</h3><ul style="list-style: none; padding: 0; margin: 20px 0; font-size: 1.1em; line-height: 2; text-align: left; max-width: 700px; margin-left: auto; margin-right: auto;"><li style="margin-bottom: 12px;">✓ <strong>First-mover advantage</strong> in autonomous bronchoscopy navigation</li><li style="margin-bottom: 12px;">✓ <strong>Proven technology</strong> validated in live animal models</li><li style="margin-bottom: 12px;">✓ <strong>Strong IP position</strong> with US patent provisional filed</li><li style="margin-bottom: 12px;">✓ <strong>Clear regulatory pathway</strong> via FDA 510(k)</li><li style="margin-bottom: 12px;">✓ <strong>Massive market opportunity</strong>: $17.6B global bronchoscopy market by 2030</li><li style="margin-bottom: 12px;">✓ <strong>Experienced leadership team</strong> with proven track records</li><li style="margin-bottom: 12px;">✓ <strong>National endorsement</strong> through maximum IIA grant</li></ul></div><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-bottom: 3px solid #6cbfa7; padding-bottom: 10px;">👥 Meet Our Leadership Team</h2><p style="margin-bottom: 25px; font-size: 1.05em;">LumenGuides is led by a team of seasoned professionals with deep expertise in medical devices, robotics, and clinical innovation:</p><div style="background: #f9f9f9; padding: 20px; border-radius: 10px; margin-bottom: 20px; border-left: 5px solid #4f9dc4;"><h3 style="font-size: 1.3em; color: #4f9dc4; margin-bottom: 10px;">Limor Prigan, ChE, MBA</h3><p style="margin: 0; font-size: 1.05em;"><strong>Founder & CEO</strong><br/>Former leadership roles at Fujifilm, Avertto, and Kornit. Expert in bringing innovative medical technologies from concept to market.</p></div><div style="background: #f9f9f9; padding: 20px; border-radius: 10px; margin-bottom: 20px; border-left: 5px solid #6cbfa7;"><h3 style="font-size: 1.3em; color: #6cbfa7; margin-bottom: 10px;">Yaniv Kirma</h3><p style="margin: 0; font-size: 1.05em;"><strong>Chief Technology Officer</strong><br/>Co-founder of Fibernova (acquired by Broncus). Pioneer in fiber-optic sensing technologies for medical applications.</p></div><div style="background: #f9f9f9; padding: 20px; border-radius: 10px; margin-bottom: 20px; border-left: 5px solid #4f9dc4;"><h3 style="font-size: 1.3em; color: #4f9dc4; margin-bottom: 10px;">Prof. Doron Kopelman</h3><p style="margin: 0; font-size: 1.05em;"><strong>Chief Medical Officer</strong><br/>Technion Faculty / HaEmek Medical Center. Renowned expert in interventional procedures and clinical innovation.</p></div><div style="background: #f9f9f9; padding: 20px; border-radius: 10px; margin-bottom: 30px; border-left: 5px solid #6cbfa7;"><h3 style="font-size: 1.3em; color: #6cbfa7; margin-bottom: 10px;">Dan Vigdor</h3><p style="margin: 0; font-size: 1.05em;"><strong>Global Business Development (USA)</strong><br/>Extensive experience in international medical device commercialization and strategic partnerships.</p></div><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865271/generated-sections/oc7dggz2z81chrj6edq8.jpg" alt="LumenGuides leadership team" style="width: 100%; max-width: 100%; height: auto; border-radius: 10px; margin: 30px 0; box-shadow: 0 6px 16px rgba(0,0,0,0.12);" /><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-bottom: 3px solid #6cbfa7; padding-bottom: 10px;">🌍 Why This Matters: The Bigger Picture</h2><p style="margin-bottom: 20px; font-size: 1.05em;">Lung cancer remains the leading cause of cancer-related deaths worldwide, claiming over 1.8 million lives annually. Early detection is critical — when caught at Stage I, the 5-year survival rate exceeds 60%. However, current diagnostic tools often fail to reach suspicious nodules in time.</p><p style="margin-bottom: 25px; font-size: 1.05em;"><strong style="color: #4f9dc4;">Naviscope represents the first step toward autonomous, radiation-free interventional pulmonology.</strong> By integrating AI, robotics, and optical sensing, LumenGuides aims to drastically improve how clinicians detect and treat early-stage lung cancer — potentially saving thousands of lives each year.</p><div style="background: linear-gradient(135deg, #4f9dc4 0%, #6cbfa7 100%); color: #ffffff; padding: 40px; border-radius: 15px; margin: 40px 0; text-align: center; box-shadow: 0 10px 30px rgba(0,0,0,0.2);"><h3 style="font-size: 1.8em; font-weight: 700; margin-bottom: 20px; color: #ffffff;">Let's Connect</h3><p style="font-size: 1.15em; margin-bottom: 25px; line-height: 1.7;">I'd welcome the opportunity to discuss how you can join us in reshaping the future of lung diagnostics. Together, we can make early lung cancer detection accessible, precise, and radiation-free.</p><div style="margin-top: 25px;"><p style="font-size: 1.1em; margin: 8px 0;"><strong>📧 Email:</strong> <a href="mailto:limor@lumenguides.com" style="color: #ffffff; text-decoration: underline;">limor@lumenguides.com</a></p><p style="font-size: 1.1em; margin: 8px 0;"><strong>📞 Phone:</strong> +972-54-731-7251</p><p style="font-size: 1.1em; margin: 8px 0;"><strong>🌐 Website:</strong> <a href="https://www.lumenguides.com" target="_blank" style="color: #ffffff; text-decoration: underline;">www.lumenguides.com</a></p></div></div><p style="margin-top: 40px; font-size: 1.05em; text-align: center; color: #31322f; font-style: italic;">📎 <strong>Attached:</strong> Investment deck, Pilot Animal Trial executive summary, and video footage from our successful animal trial.</p><hr style="border: none; border-top: 2px solid #6cbfa7; margin: 50px 0;" /><p style="text-align: center; font-size: 0.95em; color: #31322f; margin-top: 30px;"><strong>Warm regards,</strong><br/><span style="font-size: 1.1em; color: #4f9dc4; font-weight: 600;">Limor Prigan, ChE, MBA</span><br/>Founder & CEO | LumenGuides</p></div>

LumenGuides celebrates breakthrough success with first autonomous robotic bronchoscopy animal pilot and maximum Israel Innovation Authority R&D grant, advancing radiation-free lung diagnostics.

LumenGuides Achieves Two Major Milestones: First Animal Pilot & ₪5.5M IIA Grant

<div style="max-width: 900px; margin: 0 auto; padding: 40px 20px; font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif; line-height: 1.8; color: #31322f;"><h1 style="font-size: 2.5em; font-weight: 700; color: #4f9dc4; margin-bottom: 20px; line-height: 1.3;">Naviscope Completes Two Additional Successful Pre-Clinical Animal Studies at Shamir Medical Center</h1><p style="font-size: 1.1em; color: #6cbfa7; margin-bottom: 40px; font-weight: 500;">LumenGuides' autonomous robotic bronchoscopy platform demonstrates precise navigation and validates transformative potential for lung diagnostics</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865083/generated-sections/1762854560607_fhanww.jpg" alt="Naviscope robotic bronchoscopy system in action" style="width: 100%; height: auto; border-radius: 8px; margin-bottom: 30px; box-shadow: 0 4px 12px rgba(0,0,0,0.1);" /><p style="margin-bottom: 25px; font-size: 1.05em;">LumenGuides has achieved another significant milestone in the development of its groundbreaking <strong>Naviscope system</strong> — a robotic platform designed for autonomous bronchoscopic navigation. Two additional pre-clinical pilot animal studies were recently completed at <strong>Shamir Medical Center (Assaf Harofeh)</strong>, demonstrating the system's ability to navigate precisely and autonomously deep into the bronchial tree, validating its potential to revolutionize lung diagnostics and minimally invasive interventions.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Study #3: In Vivo Autonomous Navigation</h2><p style="margin-bottom: 20px; font-size: 1.05em;">The third study was performed on a <strong>live anesthetized pig (in vivo)</strong>, providing a realistic simulation of clinical conditions. The Naviscope system successfully navigated autonomously to defined targets in both lungs, reaching the <strong>fifth bronchial bifurcation within less than one minute per side</strong>.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865083/generated-sections/1762854560919_dtxdww.jpg" alt="In vivo bronchoscopic navigation study results" style="width: 100%; height: auto; border-radius: 8px; margin: 25px 0; box-shadow: 0 4px 12px rgba(0,0,0,0.1);" /><p style="margin-bottom: 20px; font-size: 1.05em;">Results were meticulously verified using <strong>3D airway modeling and X-ray imaging</strong>, showing full concordance with manual navigation performed by <strong>Prof. Mordechai Kramer</strong> using a standard single-use bronchoscope (AMBU). This validation underscores the system's reliability and precision in matching expert-level manual procedures.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Study #2: Simulated Pulmonary Lesion Navigation</h2><p style="margin-bottom: 20px; font-size: 1.05em;">The second study was conducted on a <strong>ventilated respiratory specimen from a live pig</strong> in which metallic coils had been pre-implanted to simulate a realistic pulmonary lesion. This setup allowed the team to test the Naviscope's ability to locate and navigate to specific targets within the lung tissue.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865083/generated-sections/1762854560721_euim26.jpg" alt="Metallic coil target simulation for bronchoscopic navigation" style="width: 100%; height: auto; border-radius: 8px; margin: 25px 0; box-shadow: 0 4px 12px rgba(0,0,0,0.1);" /><p style="margin-bottom: 20px; font-size: 1.05em;">After a minor mechanical correction, the Naviscope completed <strong>accurate autonomous navigation to the metallic target</strong>, confirmed both visually and radially. This achievement demonstrates the system's adaptability and precision in targeting lesions that mimic real-world clinical scenarios.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Key Findings and Clinical Implications</h2><p style="margin-bottom: 20px; font-size: 1.05em;">The results from these two studies highlight several critical capabilities of the Naviscope system:</p><ul style="margin-bottom: 25px; padding-left: 25px; font-size: 1.05em;"><li style="margin-bottom: 12px;"><strong>Reliable autonomous navigation</strong> to deep airway regions with high precision and stability</li><li style="margin-bottom: 12px;"><strong>Equivalent accuracy and speed</strong> compared with expert manual bronchoscopy supported by radiation protocols</li><li style="margin-bottom: 12px;"><strong>Strong feasibility</strong> for future clinical translation in early lung cancer diagnosis and minimally invasive procedures</li></ul><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762865111/generated-sections/1762854552131_kde9dq.jpg" alt="LumenGuides team celebrating successful pre-clinical studies" style="width: 100%; height: auto; border-radius: 8px; margin: 25px 0; box-shadow: 0 4px 12px rgba(0,0,0,0.1);" /><p style="margin-bottom: 20px; font-size: 1.05em;">These findings represent a significant step forward in the journey toward making <strong>autonomous, robotic bronchoscopy a clinical reality</strong>. The ability to navigate autonomously without relying on external imaging or radiation exposure positions Naviscope as a potentially transformative tool in interventional pulmonology.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Next Steps: Scaling Toward Clinical Translation</h2><p style="margin-bottom: 20px; font-size: 1.05em;">Following these successful studies, the LumenGuides team is now ramping up efforts to establish its <strong>assembly facility at Kibbutz Nir-Am</strong>. The focus is on continued development, implementation of a robust <strong>Quality Management System (QMS)</strong>, and rigorous <strong>Verification and Validation (V&V) processes</strong>.</p><p style="margin-bottom: 20px; font-size: 1.05em;">These steps are essential to ensure that the Naviscope system meets the stringent regulatory and clinical standards required for human use. The team is committed to advancing the technology toward <strong>first-in-human pilot studies</strong> and eventual <strong>FDA 510(k) submission</strong>.</p><h2 style="font-size: 1.9em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Join the Mission: Seeking Strategic Investors</h2><p style="margin-bottom: 20px; font-size: 1.05em;">LumenGuides is currently seeking <strong>strategic investors to complete its seed round</strong>. If you're passionate about autonomous robotics in medicine and want to shape the future of lung cancer procedures, this is an opportunity to be part of a groundbreaking innovation that has the potential to save thousands of lives each year.</p><p style="margin-bottom: 20px; font-size: 1.05em;">The global bronchoscopy market is projected to reach <strong>$17.6 billion by 2030</strong>, with a compound annual growth rate of 7.4%. Naviscope addresses critical gaps in current lung biopsy procedures, offering a <strong>radiation-free, cost-effective, and more accurate alternative</strong> to traditional methods.</p><div style="background: linear-gradient(135deg, #4f9dc4 0%, #6cbfa7 100%); padding: 30px; border-radius: 10px; margin: 40px 0; text-align: center;"><h3 style="color: #ffffff; font-size: 1.6em; margin-bottom: 15px; font-weight: 600;">Ready to Transform Lung Cancer Diagnostics?</h3><p style="color: #ffffff; font-size: 1.1em; margin-bottom: 20px;">Contact us to learn more about investment opportunities and how you can be part of this revolutionary technology.</p><p style="color: #ffffff; font-size: 1.05em; margin-bottom: 5px;"><strong>Email:</strong> limor@lumenguides.com</p><p style="color: #ffffff; font-size: 1.05em; margin-bottom: 5px;"><strong>Phone:</strong> +972-54-731-7251</p><p style="color: #ffffff; font-size: 1.05em;"><strong>Website:</strong> <a href="https://lumenguides.com/" style="color: #ffffff; text-decoration: underline;">lumenguides.com</a></p></div><p style="margin-top: 40px; font-size: 0.95em; color: #6cbfa7; font-style: italic;"><strong>About LumenGuides:</strong> LumenGuides is developing Naviscope, the first autonomous, single-use, radiation-free robotic navigation platform for bronchoscopy. By combining fiber-optic sensing, AI-powered guidance, and robotic precision, LumenGuides aims to enable earlier detection and treatment of lung cancer through minimally invasive procedures.</p></div>

LumenGuides' Naviscope system demonstrates precise autonomous bronchoscopic navigation in animal studies, validating its potential to transform lung diagnostics and interventions.

Naviscope Completes Two Successful Pre-Clinical Studies at Shamir Medical Center

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<h1 style="font-size: 2.8em; margin: 0 0 20px 0; font-weight: bold; line-height: 1.2;">LumenGuides Achieves Two Major Milestones in Autonomous Lung Diagnostics</h1>
<p style="font-size: 1.2em; margin: 0; opacity: 0.95;">First successful animal pilot and prestigious IIA grant mark breakthrough moments for revolutionary Naviscope technology</p>
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<h2 style="color: #4f9dc4; font-size: 2em; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 20px;">A Turning Point for Autonomous Lung Diagnostics</h2>
<p style="font-size: 1.1em; margin-bottom: 20px;">We are thrilled to announce two transformative milestones that validate LumenGuides' vision and accelerate our mission to revolutionize early lung cancer detection. These achievements represent years of innovation, dedication, and collaboration coming to fruition.</p>
<p style="font-size: 1.1em; margin-bottom: 20px;">Founded earlier this year, LumenGuides has rapidly emerged as a pioneer in autonomous bronchoscopy technology. Our <strong>Naviscope system</strong> &mdash; the world's first autonomous, radiation-free, single-use navigation platform &mdash; is designed to overcome the limitations of current diagnostic methods and reach peripheral lung lesions that have historically been inaccessible.</p>
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<h2 style="color: #4f9dc4; font-size: 2em; margin-bottom: 25px; text-align: center;">🎯 Milestone #1: First Pre-Clinical Animal Pilot</h2>
<p style="font-size: 1.15em; margin-bottom: 20px; text-align: center; color: #6cbfa7; font-weight: 600;">September 4, 2025 | Shamir Medical Center (Asaf Harofeh)</p>
<p style="font-size: 1.1em; margin-bottom: 20px;">On September 4, 2025, our team achieved a historic breakthrough: <strong>Naviscope successfully navigated deep into the lung of our first in-vivo animal model</strong> at Shamir Medical Center. This wasn't just a test &mdash; it was proof of concept for a technology that could transform interventional pulmonology.</p>
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<h3 style="color: #31322f; font-size: 1.5em; margin-bottom: 20px;">What Made This Achievement Groundbreaking:</h3>
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<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; color: #6cbfa7; font-weight: bold;">✓</span> <strong>Autonomous Navigation:</strong> The device independently advanced through multiple airway branches without manual guidance</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; color: #6cbfa7; font-weight: bold;">✓</span> <strong>Precision Under Motion:</strong> Maintained accuracy despite continuous respiratory movement</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; color: #6cbfa7; font-weight: bold;">✓</span> <strong>Zero Radiation:</strong> No fluoroscopy, CT, or external imaging required</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; color: #6cbfa7; font-weight: bold;">✓</span> <strong>Operator-Independent:</strong> Success not dependent on physician skill level or experience</li>
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<p style="font-size: 1.1em; margin-bottom: 20px;">This validation confirms that our <strong>fiber-optic sensor technology (FBGs) combined with AI-powered guidance</strong> can deliver on the core promise: reaching peripheral lung lesions safely, precisely, and without the limitations of current bronchoscopy systems.</p>
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<h2 style="color: #4f9dc4; font-size: 2em; margin-bottom: 25px; text-align: center;">🏆 Milestone #2: Israel Innovation Authority Grant</h2>
<p style="font-size: 1.15em; margin-bottom: 20px; text-align: center; color: #6cbfa7; font-weight: 600;">September 11, 2025 | Maximum R&amp;D Grant Awarded</p>
<p style="font-size: 1.1em; margin-bottom: 20px;">Just one week after our successful animal pilot, we received exceptional news: <strong>LumenGuides has been awarded the maximum Seed Track R&amp;D grant of ₪5.5M from the Israel Innovation Authority (IIA)</strong>.</p>
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<h3 style="color: #31322f; font-size: 1.5em; margin-bottom: 20px;">What This Grant Represents:</h3>
<ul style="font-size: 1.1em; line-height: 2;">
<li style="margin-bottom: 15px;"><strong>National Endorsement:</strong> Recognition of our technology's potential impact on healthcare</li>
<li style="margin-bottom: 15px;"><strong>Team Validation:</strong> Confidence in our leadership and execution capabilities</li>
<li style="margin-bottom: 15px;"><strong>Clinical Vision:</strong> Support for our clear regulatory pathway and clinical strategy</li>
<li style="margin-bottom: 15px;"><strong>Accelerated Development:</strong> Resources to advance toward GLP studies and design freeze</li>
</ul>
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<p style="font-size: 1.1em; margin-bottom: 20px;">This grant is more than funding &mdash; it's a powerful vote of confidence from one of the world's leading innovation authorities. It validates our approach and accelerates our timeline toward clinical trials and regulatory approval.</p>
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<h2 style="color: #4f9dc4; font-size: 2em; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 20px;">About LumenGuides &amp; Naviscope Technology</h2>
<p style="font-size: 1.1em; margin-bottom: 20px;">LumenGuides is pioneering the next generation of interventional pulmonology through <strong>Naviscope</strong> &mdash; an autonomous, radiation-free, single-use navigation system designed specifically for early lung cancer detection.</p>
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<h3 style="color: #31322f; font-size: 1.5em; margin-bottom: 20px;">How Naviscope Works:</h3>
<p style="font-size: 1.1em; margin-bottom: 15px;">Our revolutionary platform combines three breakthrough technologies:</p>
<ol style="font-size: 1.1em; line-height: 2;">
<li style="margin-bottom: 15px;"><strong>Fiber-Optic Sensors (FBGs):</strong> Provide real-time 3D airway mapping from inside the lungs</li>
<li style="margin-bottom: 15px;"><strong>AI-Powered Guidance:</strong> Enables autonomous navigation through complex bronchial pathways</li>
<li style="margin-bottom: 15px;"><strong>Single-Use Design:</strong> Eliminates cross-contamination risks and reduces procedural costs</li>
</ol>
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<p style="font-size: 1.1em; margin-bottom: 20px;">Current bronchoscopy systems &mdash; even robotic ones &mdash; fail to reach approximately <strong>40% of peripheral lung nodules</strong>. Naviscope is designed to bridge this critical gap, accessing lesions that were previously unreachable without invasive surgery.</p>
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<h2 style="font-size: 2em; margin-bottom: 25px; text-align: center; color: #ffffff;">Our Roadmap: What's Next</h2>
<p style="font-size: 1.1em; margin-bottom: 30px; text-align: center;">With these milestones achieved, we're accelerating toward commercial readiness</p>
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<h3 style="font-size: 1.3em; margin-bottom: 15px; color: #ffffff;">📋 GLP Pre-Clinical Studies</h3>
<p style="font-size: 1em; line-height: 1.6;">Comprehensive validation studies to demonstrate safety and efficacy</p>
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<h3 style="font-size: 1.3em; margin-bottom: 15px; color: #ffffff;">🔧 Design Freeze</h3>
<p style="font-size: 1em; line-height: 1.6;">Finalize platform specifications for regulatory submission</p>
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<h3 style="font-size: 1.3em; margin-bottom: 15px; color: #ffffff;">🏥 30-Patient Clinical Pilot</h3>
<p style="font-size: 1em; line-height: 1.6;">Multi-site clinical trial demonstrating real-world performance</p>
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<h3 style="font-size: 1.3em; margin-bottom: 15px; color: #ffffff;">📄 FDA 510(k) Submission</h3>
<p style="font-size: 1em; line-height: 1.6;">Clear regulatory pathway to U.S. market approval</p>
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<h2 style="font-size: 2.2em; margin-bottom: 20px; color: #ffffff;">Join Us in Reshaping Lung Diagnostics</h2>
<p style="font-size: 1.2em; margin-bottom: 30px; line-height: 1.8;">We are currently raising <strong>$1.5M</strong> to complete our <strong>$4M Seed Round</strong>, building on the ~$1M already raised. This round is scheduled to close on <strong>February 1, 2026</strong>.</p>
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<h3 style="font-size: 1.5em; margin-bottom: 20px; color: #ffffff;">Why Invest in LumenGuides?</h3>
<ul style="font-size: 1.1em; line-height: 2; text-align: left; list-style-type: none; padding-left: 0;">
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-weight: bold;">💡</span> First-of-its-kind autonomous bronchoscopy platform</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-weight: bold;">✅</span> Proven technology with successful in-vivo validation</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-weight: bold;">🏆</span> Maximum IIA grant demonstrating national confidence</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-weight: bold;">📈</span> Clear FDA 510(k) regulatory pathway</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-weight: bold;">🌍</span> Addressing $62.5B global market opportunity</li>
<li style="margin-bottom: 15px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-weight: bold;">👥</span> Experienced leadership team with proven track record</li>
</ul>
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<p style="font-size: 1.15em; margin-top: 30px; font-weight: 600;">We welcome the opportunity to discuss how you can join us in this transformative journey.</p>
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<h2 style="color: #4f9dc4; font-size: 2em; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 20px;">The Impact: Why This Matters</h2>
<p style="font-size: 1.1em; margin-bottom: 20px;">Lung cancer remains the leading cause of cancer deaths worldwide, with early detection being the single most critical factor in patient survival. Yet current diagnostic methods leave a dangerous gap:</p>
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<ul style="font-size: 1.1em; line-height: 2;">
<li style="margin-bottom: 15px;"><strong>40% of peripheral nodules</strong> remain inaccessible to standard bronchoscopy</li>
<li style="margin-bottom: 15px;"><strong>Competing procedures</strong> can exceed $20,000 and carry higher risks</li>
<li style="margin-bottom: 15px;"><strong>Radiation exposure</strong> from fluoroscopy and CT guidance poses cumulative health risks</li>
<li style="margin-bottom: 15px;"><strong>Operator dependency</strong> creates inconsistent outcomes across facilities</li>
</ul>
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<p style="font-size: 1.1em; margin-bottom: 20px;">Naviscope addresses each of these challenges head-on. By combining <strong>robotics, AI, and fiber-optic sensing</strong>, we're creating a paradigm shift in how clinicians detect and treat early-stage lung cancer &mdash; potentially saving thousands of lives each year.</p>
<p style="font-size: 1.1em; margin-bottom: 20px; font-style: italic; color: #4f9dc4; font-weight: 600;">"This is not just about better technology &mdash; it's about giving patients a fighting chance through earlier, more accurate diagnosis."</p>
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<footer style="background-color: #31322f; color: #ffffff; padding: 40px; border-radius: 12px; text-align: center;">
<h2 style="font-size: 1.8em; margin-bottom: 25px; color: #6cbfa7;">Let's Connect</h2>
<p style="font-size: 1.1em; margin-bottom: 30px; line-height: 1.8;">I'd be delighted to share more about our technology, clinical strategy, and investment opportunity. Our comprehensive deck, pilot animal trial executive summary, and video documentation are available upon request.</p>
<div style="margin: 30px 0; padding: 30px; background-color: rgba(108,191,167,0.1); border-radius: 8px;">
<p style="font-size: 1.3em; margin-bottom: 10px; font-weight: 600; color: #6cbfa7;">Limor Prigan, ChE, MBA</p>
<p style="font-size: 1.1em; margin-bottom: 20px;">Founder &amp; CEO | LumenGuides</p>
<p style="font-size: 1.1em; margin-bottom: 10px;">📞 <a style="color: #6cbfa7; text-decoration: none;" href="tel:+972547317251">+972-54-731-7251</a></p>
<p style="font-size: 1.1em; margin-bottom: 10px;">📧 <a style="color: #6cbfa7; text-decoration: none;" href="mailto:limor@lumenguides.com">limor@lumenguides.com</a></p>
<p style="font-size: 1.1em;">🌐 <a style="color: #6cbfa7; text-decoration: none;" href="https://www.lumenguides.com" target="_blank" rel="noopener">www.lumenguides.com</a></p>
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<p style="font-size: 1em; margin-top: 30px; opacity: 0.8;">Together, we can reshape the future of lung diagnostics and save lives through innovation.</p>
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LumenGuides announces successful first animal pilot of Naviscope autonomous bronchoscopy system and secures maximum ₪5.5M IIA grant, marking breakthrough moments in lung cancer detection.

LumenGuides Achieves Two Major Milestones in Autonomous Lung Diagnostics

<div style="max-width: 900px; margin: 0 auto; padding: 40px 20px; font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif; line-height: 1.8; color: #31322f;"><h1 style="font-size: 2.5em; font-weight: 700; color: #4f9dc4; margin-bottom: 20px; line-height: 1.3; border-bottom: 4px solid #6cbfa7; padding-bottom: 15px;">Autonomous Robotic Navigation Takes Another Leap Forward: Naviscope Completes Groundbreaking Pre-Clinical Studies</h1><p style="font-size: 1.1em; color: #31322f; margin-bottom: 30px; font-style: italic;">LumenGuides' revolutionary Naviscope system demonstrates precise, autonomous navigation in bronchial procedures, marking a significant milestone in the future of lung diagnostics and minimally invasive interventions.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762876014/generated-sections/1762854560607_kjokvv.jpg" alt="Naviscope robotic bronchoscopy system in action" style="width: 100%; height: auto; border-radius: 8px; margin: 30px 0; box-shadow: 0 4px 12px rgba(0,0,0,0.15);" /><h2 style="font-size: 2em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Breaking New Ground in Autonomous Bronchoscopy</h2><p style="margin-bottom: 20px;">In a remarkable demonstration of medical robotics innovation, <strong>LumenGuides' Naviscope system</strong> has successfully completed two additional pre-clinical pilot animal studies at <strong>Shamir Medical Center (Assaf Harofeh)</strong>. These studies represent a pivotal advancement in autonomous bronchoscopic navigation, showcasing the platform's ability to navigate deep into the bronchial tree with unprecedented precision and reliability.</p><p style="margin-bottom: 20px;">The Naviscope system is a robotic platform specifically designed to enhance precision and accessibility in lung diagnostics and minimally invasive interventions. By combining <strong>AI-powered guidance, fiber-optic sensing, and autonomous robotics</strong>, LumenGuides is addressing critical gaps in current lung cancer diagnosis and treatment procedures.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762876015/generated-sections/1762854560919_sirjwv.jpg" alt="Pre-clinical study setup at Shamir Medical Center" style="width: 100%; height: auto; border-radius: 8px; margin: 30px 0; box-shadow: 0 4px 12px rgba(0,0,0,0.15);" /><h2 style="font-size: 2em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Study Results: Precision Meets Performance</h2><h3 style="font-size: 1.5em; font-weight: 600; color: #6cbfa7; margin-top: 35px; margin-bottom: 15px;">Study #3: In Vivo Autonomous Navigation</h3><p style="margin-bottom: 20px;">The third study was conducted on a <strong>live anesthetized pig (in vivo)</strong>, providing the most realistic test environment for evaluating the Naviscope's capabilities. The results were nothing short of impressive:</p><ul style="margin-bottom: 25px; padding-left: 30px; list-style-type: disc;"><li style="margin-bottom: 12px;"><strong>Autonomous navigation to defined targets</strong> in both lungs was achieved successfully</li><li style="margin-bottom: 12px;">The system reached the <strong>fifth bronchial bifurcation within less than one minute per side</strong></li><li style="margin-bottom: 12px;">Results were verified using <strong>3D airway modeling and X-ray imaging</strong></li><li style="margin-bottom: 12px;">Full concordance was demonstrated with manual navigation performed by <strong>Prof. Mordechai Kramer</strong> using a standard single-use bronchoscope (AMBU)</li></ul><p style="margin-bottom: 20px;">This study validated that Naviscope can match the accuracy and speed of expert manual bronchoscopy while operating autonomously—a critical milestone for future clinical translation.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762876015/generated-sections/1762854560721_jjekpz.jpg" alt="3D airway modeling and navigation visualization" style="width: 100%; height: auto; border-radius: 8px; margin: 30px 0; box-shadow: 0 4px 12px rgba(0,0,0,0.15);" /><h3 style="font-size: 1.5em; font-weight: 600; color: #6cbfa7; margin-top: 35px; margin-bottom: 15px;">Study #2: Simulated Lesion Targeting</h3><p style="margin-bottom: 20px;">The second study was conducted on a <strong>ventilated respiratory specimen from a live pig</strong> in which metallic coils had been pre-implanted to simulate a realistic pulmonary lesion. This setup allowed researchers to test the system's ability to locate and navigate to specific targets within the lung tissue.</p><p style="margin-bottom: 20px;">After a minor mechanical correction, Naviscope completed <strong>accurate autonomous navigation to the metallic target</strong>, with results confirmed both visually and radially. This demonstrates the platform's potential for precisely targeting lung nodules and lesions—a critical capability for early lung cancer diagnosis.</p><h2 style="font-size: 2em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Key Findings and Clinical Implications</h2><p style="margin-bottom: 20px;">The combined results from these studies highlight several critical achievements that position Naviscope as a transformative technology in interventional pulmonology:</p><div style="background: linear-gradient(135deg, #4f9dc4 0%, #6cbfa7 100%); padding: 30px; border-radius: 10px; margin: 30px 0; color: #ffffff;"><ul style="list-style-type: none; padding: 0; margin: 0;"><li style="margin-bottom: 18px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-size: 1.3em;">✓</span> <strong>Reliable autonomous navigation</strong> to deep airway regions with high precision and stability</li><li style="margin-bottom: 18px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-size: 1.3em;">✓</span> <strong>Equivalent accuracy and speed</strong> compared with expert manual bronchoscopy supported by radiation protocols</li><li style="margin-bottom: 18px; padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-size: 1.3em;">✓</span> <strong>Strong feasibility</strong> for future clinical translation in early lung cancer diagnosis and minimally invasive procedures</li><li style="padding-left: 30px; position: relative;"><span style="position: absolute; left: 0; font-size: 1.3em;">✓</span> <strong>Radiation-free operation</strong>, eliminating patient and clinician exposure to harmful imaging radiation</li></ul></div><p style="margin-bottom: 20px;">These findings are particularly significant given the current limitations in bronchoscopy. Traditional systems fail to reach approximately <strong>40% of lung nodules</strong>, and competing procedures can exceed <strong>$20,000</strong> while posing higher risks to patients. Naviscope addresses these critical gaps by offering a more accessible, cost-effective, and safer alternative.</p><img src="https://res.cloudinary.com/salesfronts/image/upload/v1762876032/generated-sections/1762854552131_c7hwem.jpg" alt="LumenGuides team advancing autonomous bronchoscopy technology" style="width: 100%; height: auto; border-radius: 8px; margin: 30px 0; box-shadow: 0 4px 12px rgba(0,0,0,0.15);" /><h2 style="font-size: 2em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">The Technology Behind the Innovation</h2><p style="margin-bottom: 20px;">What sets Naviscope apart is its unique integration of cutting-edge technologies:</p><ul style="margin-bottom: 25px; padding-left: 30px; list-style-type: disc;"><li style="margin-bottom: 12px;"><strong>Fiber-optic sensing (FBG)</strong> provides real-time 3D airway mapping from inside the lungs</li><li style="margin-bottom: 12px;"><strong>AI-powered robotic guidance</strong> ensures autonomous, accurate navigation without external imaging</li><li style="margin-bottom: 12px;"><strong>No CT, fluoroscopy, or electromagnetic navigation (EMN)</strong> required—making procedures faster and safer</li><li style="margin-bottom: 12px;"><strong>Single-use design</strong> eliminates cross-contamination risks and simplifies workflow</li></ul><p style="margin-bottom: 20px;">This first-of-its-kind autonomous navigation system represents a meaningful step forward in early lung cancer detection, potentially redefining how clinicians access and treat deep pulmonary nodules.</p><h2 style="font-size: 2em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Looking Ahead: From Lab to Clinical Reality</h2><p style="margin-bottom: 20px;">Following these successful studies, the LumenGuides team is now <strong>ramping up toward establishing its assembly facility at Kibbutz Nir-Am</strong>. The focus is on continued development, Quality Management System (QMS) implementation, and Verification & Validation (V&V) processes—all critical steps in the journey to make autonomous robotic bronchoscopy a clinical reality.</p><p style="margin-bottom: 20px;">The upcoming milestones include:</p><ul style="margin-bottom: 25px; padding-left: 30px; list-style-type: disc;"><li style="margin-bottom: 12px;">Platform and design freeze with comprehensive V&V protocols</li><li style="margin-bottom: 12px;">First-in-human pilot study with 30 patients</li><li style="margin-bottom: 12px;">FDA 510(k) submission</li><li style="margin-bottom: 12px;">Expanded pre-clinical studies to further validate safety and efficacy</li></ul><p style="margin-bottom: 20px;">With the global bronchoscopy market projected to reach <strong>$17.6 billion by 2030</strong> (7.4% CAGR), and with <strong>500,000 annual procedures in the U.S. alone</strong>, the commercial opportunity for Naviscope is substantial.</p><div style="background-color: #f8f9fa; border-left: 5px solid #6cbfa7; padding: 25px; margin: 40px 0; border-radius: 5px;"><h3 style="font-size: 1.4em; font-weight: 600; color: #4f9dc4; margin-top: 0; margin-bottom: 15px;">Join the Revolution in Lung Cancer Diagnostics</h3><p style="margin-bottom: 15px;">LumenGuides is currently seeking <strong>strategic investors to complete its seed round</strong>. If you're passionate about autonomous robotics in medicine and want to shape the future of lung cancer procedures, this is an opportunity to be part of a transformative innovation.</p><p style="margin-bottom: 10px;"><strong>Contact:</strong></p><p style="margin-bottom: 5px;">Limor Prigan, ChE, MBA<br />Founder & CEO | LumenGuides</p><p style="margin-bottom: 5px;">📞 +972-54-731-7251</p><p style="margin-bottom: 5px;">📧 <a href="mailto:limor@lumenguides.com" style="color: #4f9dc4; text-decoration: none;">limor@lumenguides.com</a></p><p>🌐 <a href="https://www.lumenguides.com" style="color: #4f9dc4; text-decoration: none;">www.lumenguides.com</a></p></div><h2 style="font-size: 2em; font-weight: 600; color: #4f9dc4; margin-top: 50px; margin-bottom: 20px; border-left: 5px solid #6cbfa7; padding-left: 15px;">Why This Matters</h2><p style="margin-bottom: 20px;">Lung cancer remains one of the leading causes of cancer-related deaths worldwide, with early detection being critical to improving survival rates. Current diagnostic methods often fall short, leaving many lesions unreachable or requiring expensive, radiation-intensive procedures.</p><p style="margin-bottom: 20px;"><strong>Naviscope represents the first step toward autonomous, radiation-free interventional pulmonology.</strong> By integrating AI, robotics, and optical sensing, LumenGuides aims to drastically improve how clinicians detect and treat early-stage lung cancer—potentially saving thousands of lives each year.</p><p style="margin-bottom: 20px;">These recent pre-clinical successes at Shamir Medical Center demonstrate that this vision is rapidly becoming reality. As the technology continues to advance through rigorous testing and validation, the medical community moves closer to a future where precise, autonomous, and safe lung diagnostics are accessible to all patients who need them.</p><p style="font-style: italic; color: #6cbfa7; font-size: 1.1em; margin-top: 40px; text-align: center;">The future of interventional pulmonology is autonomous, precise, and radiation-free—and it's arriving sooner than you think.</p></div>

LumenGuides' Naviscope completes successful pre-clinical studies at Shamir Medical Center, demonstrating precise autonomous bronchoscopic navigation for lung diagnostics.

Autonomous Robotic Navigation Takes Another Leap Forward with Naviscope

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<div style="background: var(--theme-bgcolor); margin: 8px; box-shadow: 0 0 4px var(--theme-color); padding: 12px; width: 14em; position: relative; border-radius: 8px;"><span style="font-size: 2em; display: block;">🔍</span><span style="font-size: 1.2em; display: block; font-weight: 600;"><strong>Expanding Diagnostic Reach</strong></span><span style="font-size: 0.9em; display: block;">Accessing previously unreachable areas, drastically reducing the need for invasive procedures.</span></div>
<div style="background: var(--theme-bgcolor); margin: 8px; box-shadow: 0 0 4px var(--theme-color); padding: 12px; width: 14em; position: relative; border-radius: 8px;"><span style="font-size: 2em; display: block;">🤖</span><span style="font-size: 1.2em; display: block; font-weight: 600;"><strong>AI-Powered Auto-Navigation</strong></span><span style="font-size: 0.9em; display: block;">Combining real-time positioning with deep learning for unmatched precision.</span></div>
<div style="background: var(--theme-bgcolor); margin: 8px; box-shadow: 0 0 4px var(--theme-color); padding: 12px; width: 14em; position: relative; border-radius: 8px;"><span style="font-size: 2em; display: block;">🌟</span><span style="font-size: 1.2em; display: block; font-weight: 600;"><strong>Radiation-Free Precision</strong></span><span style="font-size: 0.9em; display: block;">Eliminating reliance on harmful imaging techniques like X-rays.</span></div>
<div style="background: var(--theme-bgcolor); margin: 8px; box-shadow: 0 0 4px var(--theme-color); padding: 12px; width: 14em; position: relative; border-radius: 8px;"><span style="font-size: 2em; display: block;">🧼</span><span style="font-size: 1.2em; display: block; font-weight: 600;"><strong>Single-Use Sterility</strong></span><span style="font-size: 0.9em; display: block;">Preventing cross-contamination and enhancing patient safety.</span></div>
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<h2 style="align-items: center; justify-content: center; margin: 50px 8px;"><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">We&rsquo;re a team of serial entrepreneurs on a mission to revolutionize endoscopy. </span></h2>
<div style="align-items: center; justify-content: center; margin: 50px 8px;"><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">Imagine a patient whose life hinges on a precise lung biopsy. Today, up to 35% of such cases require invasive surgeries like thoracotomies, which are riskier, costlier, and lead to higher complication rates. We&rsquo;re changing that.&nbsp;</span><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">LumenGuides' autonomous, location-aware bronchoscope is redefining lung diagnostics and treatment by: </span></div>
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<li style="align-items: center; justify-content: center; text-align: left;"><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">Expanding Diagnostic Reach: Accessing previously unreachable areas, drastically reducing the need for invasive procedures. </span></li>
<li style="align-items: center; justify-content: center; text-align: left;"><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">AI-Powered Auto-Navigation: Combining real-time positioning with deep learning for unmatched precision. </span></li>
<li style="align-items: center; justify-content: center; text-align: left;"><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">Radiation-Free Precision: Eliminating reliance on harmful imaging techniques like X-rays. </span></li>
<li style="align-items: center; justify-content: center; text-align: left;"><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">Single-Use Sterility: Preventing cross-contamination and enhancing patient safety. </span></li>
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<div style="align-items: center; justify-content: center; margin: 50px 8px;"><span style="display: block; text-align: center; font-size: 12pt; font-weight: 600;">With a proven proof of concept and a bootstrap-funded team of serial entrepreneurs, we&rsquo;re positioned to disrupt a $62.5B global market. Over 500,000 bronchoscopy procedures are performed annually in the U.S. , offering significant growth opportunities.</span></div>
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<h2 style="font-size: 1.6em; padding: 10px 0px; margin: 0px;"><span style="font-size: 12pt;">Special Features</span></h2>
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<div style="font-size: 0.9em; margin: 10px 10px; text-align: center; width: 15em;"><span style="font-size: 2.0em;">📍</span><br><span style="font-size: 1.2em;"><strong>Precision Navigation</strong></span><br>Our bronchoscope navigates with pinpoint accuracy.</div>
<div style="font-size: 0.9em; margin: 10px 10px; text-align: center; width: 15em;"><span style="font-size: 2.0em;">🧠</span><br><span style="font-size: 1.2em;"><strong>AI Integration</strong></span><br>Harnessing AI for smarter, safer procedures.</div>
<div style="font-size: 0.9em; margin: 10px 10px; text-align: center; width: 15em;"><span style="font-size: 2.0em;">❤️</span><br><span style="font-size: 1.2em;"><strong>Patient-Centric Design</strong></span><br>Designed with patient safety and comfort in mind.</div>
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